发明名称 |
COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS |
摘要 |
Compounds of formula (I), ( theta ) wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X<1> is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR2, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or =O, or by one or more aliphatic or aromatic 5-or 6-membered rings optionally containing 1-2 heteroatoms; R<1> is (a). These compounds are selective inhibitors of p38 alpha kinase.
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申请公布号 |
WO0059904(A2) |
申请公布日期 |
2000.10.12 |
申请号 |
WO2000US07934 |
申请日期 |
2000.03.24 |
申请人 |
SCIOS INC.;MAVUNKEL, BABU, J.;LIU, DAVID, Y.;SCHREINER, GEORGE, F.;LEWICKI, JOHN, A. |
发明人 |
MAVUNKEL, BABU, J.;LIU, DAVID, Y.;SCHREINER, GEORGE, F.;LEWICKI, JOHN, A. |
分类号 |
A61K31/4427;A61K31/454;A61K31/4545;A61K31/496;A61P1/04;A61P9/02;A61P9/10;A61P11/00;A61P13/12;A61P17/06;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P25/00;A61P27/02;A61P29/00;A61P31/04;A61P33/06;A61P37/06;C07D209/08;C07D209/24;C07D235/06;C07D401/06;C07D401/14;C07D403/06;C07D471/04;(IPC1-7):C07D471/04;A61K31/437 |
主分类号 |
A61K31/4427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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