发明名称 |
STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1 - (4-FLUOROPHENYL) - 3(R)-[3(S) - HYDROXY-3 - (4-FLUOROPHENYL) PROPYL)]-4(S) - (4-HYDROXYPHENYL)-2-AZETIDINONE |
摘要 |
A process for the stereoselective microbial reduction of compound of formula (II) to compound of formula (I) comprising adding compound of formula (II) to a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus fascians ATCC No.202210 or fungal isolate Geotrichum candidum ATCC No. 74487, incubating the resulting mixture, and isolating a hydroxy compound of formula (I), is described. The compound of formula (I) is a serum cholesterol lowering agent.
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申请公布号 |
WO0060107(A1) |
申请公布日期 |
2000.10.12 |
申请号 |
WO1999US07445 |
申请日期 |
1999.04.05 |
申请人 |
SCHERING CORPORATION;HOMANN, MICHAEL, J.;PREVITE, EDWARD |
发明人 |
HOMANN, MICHAEL, J.;PREVITE, EDWARD |
分类号 |
C07D205/08;C12P17/10;C12R1/01;(IPC1-7):C12P17/10 |
主分类号 |
C07D205/08 |
代理机构 |
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主权项 |
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地址 |
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