Human sodium-phosphate cotransporter Npt2B, useful e.g. for identifying agents for treating hyper- and hypo-phosphatemia, and related nucleic acid

摘要

Npt2B polypeptide (I) having a 688 amino acid sequence (1), reproduced in the specification, is new. Independent claims are also included for the following: (1) Npt2B polypeptide (I') at least 90% identical with (I); (2) Npt2B polypeptide (I'') comprising sequence (1); (3) fragments (II) of (I), (I') and (I''); (4) nucleic acids (III) encoding (I), (I'), (I'') or their fragments; (5) fragments of (III); (6) isolated nucleic acid or its mimetics, (III'), that hybridize to (III) or its complement under stringent conditions; (7) expression cassette (EC) containing (III), its fragments or (III'); (8) cells that contain EC, as part of an extrachromosomal element or integrated into the genome, and their progeny; (9) production of Npt2B by culturing cells of (h); (10) monoclonal antibody (MAb) that binds specifically to Npt2B; (11) (l) modulating Npt2B in a host by administering a specific modulatory agent (A); (12) screening for identifying (A); and (13) a non-human transgenic animal that expresses Npt2B. - ACTIVITY : Anti-hyperphosphatemia; anti-hypophosphatemia. - MECHANISM OF ACTION : Npt2B is a human type II sodium-phosphate cotransporter, responsible for absorption and uptake of inorganic phosphate in the intestine. No data given.