发明名称 |
PHARMACEUTICAL FORMULATIONS AND PROCESSES FOR THEIR PREPARATION |
摘要 |
Provided is a pharmaceutical composition comprising a tablet or capsule containing a pharmacologically effective amount of a pharmaceutical compound, or a pharmaceutically acceptable salt thereof, having an amidine-based group and an optional ester group, a pharmaceutically acceptable solid carrier, and a pharmaceutically acceptable acid in an amount to modify the pH of the composition to substantially that of the compound at pH of maximum stability. Such a composition is prepared by adding water during formulation manufacture and contacting the compound during formulation manufacture with a pharmaceutically acceptable acid having a pH in a saturated aqueous solution substantially that of the compound at pH of maximum stability. |
申请公布号 |
EP1042002(A1) |
申请公布日期 |
2000.10.11 |
申请号 |
EP19990901467 |
申请日期 |
1999.01.14 |
申请人 |
DU PONT PHARMACEUTICALS COMPANY |
发明人 |
BADAWY, SHERIF I.;GILBERT, DONNA, L. |
分类号 |
A61K9/20;A61K9/48;A61K31/42;A61K47/12;A61P43/00;C07D261/04 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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