Sulfonylaminopyridines, process of their preparation and use as well as pharmaceutical preparations based thereon

摘要

In the present invention there are disclosed sulfonylaminopyridines of the general formula I, in which the individual symbols have specific meaning, further a process for preparing such sulfonylaminopyridines that is characterized in that the compound of the general formula II (a) is brought into reaction with isocyanate of the general formula (Re10Re11)NCOCl, or (b) is brought into reaction with phosgene and subsequently with the alcohol of the general formula Re10OH or with ester of formic acid of the general formula Re10OC(O)Cl and optionally in the obtained compound of the general formula I the substituents being present therein are changed or optionally the compound of the general formula I is transferred to and pharmaceutically acceptable salt. In the present invention there are also claimed pharmaceutical preparations in which those sulfonylaminopyridines and usual carriers and auxiliary substances are comprised as well as use of those sulfonylaminopyridines as active substances for the preparation of medicaments intended for treating diseases that are connected with endothelin activities, particularly circulation diseases such as hypertonia, ischemia, vasospasm and angina pectoris.