发明名称 |
Medicament, levorotatory enantiomer of dimethylbenzofuran or dimethylbenzopyran derivative, process and intermediates for its preparation and pharmaceutical preparations containing thereof |
摘要 |
In the present invention there is disclosed the use of dimethylbenzofuran or dimethylbenzopyran derivative of the general formula I, in which Re1 and Re2 represents each a hydrogen atom or both together represent a bivalent group of the general formula -CH=CH-CH=CH-, -CH=C(Cl)-CH=CH- or -CH=CH-C(Cl)=CH-, n is 2, 3 or 4, Re3 represents a hydrogen atom or a methoxy group, m is the number 1 or 2, Re4 represents a hydrogen atom, an amino group or an alkylcarbonylamino group containing 1 to 3 carbon atoms in the alkyl part, and Re5 represents a hydrogen or halogen atom or their pharmaceutically acceptable acid addition salts or stereochemically isomeric forms for preparing a medicament intended for treating diseases mediated by 5-HTi3. In the present invention there are also claimed levorotatory enantiomers of derivatives of the general formula I, process and intermediates for their preparation as well as pharmaceutical preparations based thereon.
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申请公布号 |
CZ287262(B6) |
申请公布日期 |
2000.10.11 |
申请号 |
CZ19950001258 |
申请日期 |
1993.11.15 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
VEN DAELE GEORGES HENRI PAUL;BOSMANS JEAN-PAUL REN• MARIE ANDR•;VAN LAERHOVEN WILLY JOANNES CAROLUS |
分类号 |
A61K31/343;A61K31/353;A61K31/4525;A61K31/4545;A61K31/505;A61K31/506;A61P1/08;A61P25/04;A61P25/18;A61P25/24;A61P25/26;A61P25/28;A61P25/30;A61P43/00;C07D;C07D211/26;C07D211/42;C07D211/58;C07D401/12;C07D405/14;(IPC1-7):C07D405/14;A61K31/452;A61P25/00 |
主分类号 |
A61K31/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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