发明名称 Medicament, levorotatory enantiomer of dimethylbenzofuran or dimethylbenzopyran derivative, process and intermediates for its preparation and pharmaceutical preparations containing thereof
摘要 In the present invention there is disclosed the use of dimethylbenzofuran or dimethylbenzopyran derivative of the general formula I, in which Re1 and Re2 represents each a hydrogen atom or both together represent a bivalent group of the general formula -CH=CH-CH=CH-, -CH=C(Cl)-CH=CH- or -CH=CH-C(Cl)=CH-, n is 2, 3 or 4, Re3 represents a hydrogen atom or a methoxy group, m is the number 1 or 2, Re4 represents a hydrogen atom, an amino group or an alkylcarbonylamino group containing 1 to 3 carbon atoms in the alkyl part, and Re5 represents a hydrogen or halogen atom or their pharmaceutically acceptable acid addition salts or stereochemically isomeric forms for preparing a medicament intended for treating diseases mediated by 5-HTi3. In the present invention there are also claimed levorotatory enantiomers of derivatives of the general formula I, process and intermediates for their preparation as well as pharmaceutical preparations based thereon.
申请公布号 CZ287262(B6) 申请公布日期 2000.10.11
申请号 CZ19950001258 申请日期 1993.11.15
申请人 JANSSEN PHARMACEUTICA N.V. 发明人 VEN DAELE GEORGES HENRI PAUL;BOSMANS JEAN-PAUL REN• MARIE ANDR•;VAN LAERHOVEN WILLY JOANNES CAROLUS
分类号 A61K31/343;A61K31/353;A61K31/4525;A61K31/4545;A61K31/505;A61K31/506;A61P1/08;A61P25/04;A61P25/18;A61P25/24;A61P25/26;A61P25/28;A61P25/30;A61P43/00;C07D;C07D211/26;C07D211/42;C07D211/58;C07D401/12;C07D405/14;(IPC1-7):C07D405/14;A61K31/452;A61P25/00 主分类号 A61K31/343
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