发明名称 |
CRYSTAL OF DIURIDINE TETRAPHOSPHATE OR SALT THEREOF AND METHOD FOR PREPARING THE SAME, AND METHOD FOR PRODUCING SAID COMPOUND |
摘要 |
The invention provides crystals of P<1>,P<4>-di(uridine 5'-)tetraphosphate or a salt thereof; a process for producing the crystals; and a process for producing P<1>,P<4>-di(uridine 5'-)tetraphosphate (U2P4) or a salt thereof from UMP serving as a starting material and by use of DPC and PPi, which process comprises at least one of the following treatment steps: (a) adding UMP diphenylphosphate (UMP-DPP) in divided portions during a step of reaction of UMP-DPP with a PPi-organic alkali salt; (b) carrying out reaction of UMP-DPP with a PPi-organic alkali salt in the presence of a base; and (c) further treating the synthesized U2P4 with an alkali. The crystals of U2P4 or a salt thereof obtained through the process according to the invention have high purity and stability and a less hygroscopicity as compared with a lyophilized product, to thereby serve as a useful raw material for preparing a pharmaceutical. The process for producing U2P4 or a salt thereof according to the invention realizes high yield and enables large-scale synthesis. |
申请公布号 |
EP1043329(A1) |
申请公布日期 |
2000.10.11 |
申请号 |
EP19990970090 |
申请日期 |
1999.10.01 |
申请人 |
YAMASA CORPORATION |
发明人 |
MAEDA, HIDEAKI;YAMADA, TOSHIO;SATO, HIROSHI;NODA, YUTAKA |
分类号 |
C07H19/10;A61P11/00;C07H21/02 |
主分类号 |
C07H19/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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