| 摘要 |
medicine. SUBSTANCE: invention relates to method of modification of protein, for example, antibody, method of providing the protein binding with antibody, pharmaceutical compositions of modified proteins used for human treatment. Invention involves lipid-bound protein where one or more acyl groups are bound with protein by means of side carbohydrate chain and different covalent bonds. Lipidized antibodies can be used for curative and diagnostic aims. EFFECT: improved method of modification, enhanced penetration of modified proteins into cells. 20 cl, 2 tbl, 4 dwg, 7 ex |
