DERIVATIVES OF 8-AZABICYCLO[3,2,1]OCT-2-ENE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DRUG PREPARING, METHODS OF INHIBITION OF REUPTAKE OF MONOAMINE NEUROMEDIATING AGENT, ESPECIALLY, SEROTONIN

摘要

organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel chemical compounds, namely 8-azabicyclo[3.2.1]oct-2-ene of the formula (I) or its any enantiomers or any their mixtures, or any pharmaceutically acceptable salts where R means hydrogen atom, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl; R4 means phenyl that can be substituted with one or more substituents taken among the group including halogen atom, CF3, CN, alkoxyl-, cycloalkoxyl-group, alkyl, cycloalkyl, alkenyl, alkynyl, nitro-group; benzyl that can be substituted with one or more substituents taken among the group including halogen atom, CF3, CN, alkoxyl-, cycloalkoxyl-group, alkyl, cycloalkyl, alkenyl, alkynyl, amino-group, nitro-group, heteroaryl and aryl under condition that if R is hydrogen atom then R4 is not phenyl, 4-fluorophenyl or 3-trifluoromethylphenyl; if R means methyl then R4 is not phenyl, 4-halogenphenyl, 4-methylphenyl, 2-ethylphenyl, 2,4-dimethylphenyl, 2,4,6-trimethylphenyl, 3-trifluoromethylphenyl or 4-methoxyphenyl; if R means ethyl then R4 is not phenyl; if R means octyl then R4 is not phenyl. These compounds show useful pharmaceutical properties as inhibitors of reuptake of monoamine neuromediating agents, especially, serotonin and can be used as agents inducing rapid antidepressing effect. EFFECT: new compounds indicated above, valuable pharmacological properties, enhanced effectiveness. 11 cl, 1 tbl, 4 ex