The present invention relates to a new two-component pharmaceutical formulation of melphalan in which the two components comprise a) freeze-dried mephalan hydrochloride and b) a solvent-diluent comprising a citrate, propylene glycol and ethanol. Substantially pure melphalan, substantially pure melphalan hydrochloride and methods for preparing them are also described.
申请公布号
CA1341114(C)
申请公布日期
2000.10.10
申请号
CA19880583540
申请日期
1988.11.18
申请人
STANLEY, TIMOTHY PAUL;DIVALL, GEOFFREY;POOLE, STEPHEN WILLIAM;KNIGHT, JOSEPH;PACKHAM, TERENCE WILLIAM
发明人
STANLEY, TIMOTHY PAUL;DIVALL, GEOFFREY;POOLE, STEPHEN WILLIAM;KNIGHT, JOSEPH;PACKHAM, TERENCE WILLIAM