| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound capable of simultaneously alkylating and cleaving both chains of DNA and useful as a therapeutic medicine for cancer. SOLUTION: This compound is represented by the formula B-L-A (B is a chemical structure capable of recognizing a base sequence of DNA; A is a chemical structure capable of binding to one kind of a base of DNA; L is a linker capable of binding chemical structures of A and B, preferably a compound of formula I or the like. For example, the compound of formula I is obtained by treating a compound of formula II (X is N) with benzotriazol-1-yloxytris(dimethylamino)phophonium hexafluorophosphonate in tetrahydrofuran and subjecting the resultant compound to treatment with NaBH4, treatment with MnO2, treatment with triethylphosphonoacetate and NaH, treatment with sodium hydroxide in water-methanol and treatment with 1,1-carbonyldiimidazole in this order and reacting the product with a compound of formula III in the presence of a sodium hydride.
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