Enantiomerically enriched alpha , alpha -distributed amino acids and method

摘要

Compositions and methods for the preparation of enantiomerically enriched alpha , alpha -disubstituted amino acid precursors are presented. Briefly, allylic electrophiles are alkylated with oxazolones in the presence of a base and catalytic quantities of a transition metal complex incorporating a chiral phosphine ligand to yield 4,4-disubstituted-5(4H)-oxazolones. These precursors may be subsequently transformed either synthetically or enzymatically to yield enantiomerically enriched alpha , alpha -disubstituted amino acids.