Treating undesirable uterine bleeding, e.g. as side-effect of hormone therapy, by intranasal administration of estradiol

摘要

The use of estradiol (I) is claimed for the preparation of an intranasally administered pharmaceutical composition for treating undesirable uterine bleeding. An Independent claim is included for a composition for use as above, in the form of an aqueous solution containing (I) (optionally as a mixture with a progestogen) and a partially and randomly methylated cyclodextrin.