发明名称 |
4-SUBSTITUTED QUINOLINE DERIVATIVES AS NK-3 AND/OR GABA(A) RECEPTOR LIGANDS |
摘要 |
The invention relates to certain novel compounds of general Formula (I) where R1, R2, R3, R4, X, Y1, and Y2 are defined herein. These compounds bind with high affinity to NK-3 receptors and/or GABAA receptors. Also provided are pharmaceutical compositions comprising them, and methods of treating patients suffering from certain central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of NK-3 receptors and GABAA receptors.
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申请公布号 |
WO0058303(A1) |
申请公布日期 |
2000.10.05 |
申请号 |
WO2000US08205 |
申请日期 |
2000.03.28 |
申请人 |
NEUROGEN CORPORATION;YUAN, JUN;MAYNARD, GEORGE, D.;HUTCHISON, ALAN;RACHWAL, STANISLAW |
发明人 |
YUAN, JUN;MAYNARD, GEORGE, D.;HUTCHISON, ALAN;RACHWAL, STANISLAW |
分类号 |
G01N33/50;A61K31/4709;A61K31/5377;A61P9/00;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P43/00;C07D401/04;C07D401/14;C07D413/04;C07D487/04;G01N33/15;G01N33/566;G01N33/94;(IPC1-7):C07D401/04;A61K31/47 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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