| 摘要 |
<p>The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.</p> |
| 申请人 |
WALTER REED ARMY INSTITUTE OF RESEARCH;ECKELS, KENNETH, H.;PUTNAK, JOSEPH, R.;INNIS, BRUCE, L. |
发明人 |
ECKELS, KENNETH, H.;PUTNAK, JOSEPH, R.;INNIS, BRUCE, L. |
