<p>The present invention provides vaccine compositions of attenuated dengue-2 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-2 virus by administration of attenuated dengue-2 virus.</p>
申请公布号
CA2365411(A1)
申请公布日期
2000.10.05
申请号
CA20002365411
申请日期
2000.03.24
申请人
WALTER REED ARMY INSTITUTE OF RESEARCH
发明人
HOKE, CHARLES H.;KANESA-THASAN, NIRANJAN;INNIS, BRUCE L.;DUBOIS, DORIA R.;ECKELS, KENNETH H.;HENCHAL, ERIK A.;VAUGHN, DAVID;PUTNAK, JOSEPH R.