ADENOVIRAL VECTORS

摘要

The present invention is directed to recombinant adenoviral vectors capable of highly effective therapeutic levels of p53. In particular, the present invention provides a replication competent recombinant adenovirus containing a constitutive viral or cellular promotor operably linked to a p53 gene, wherein said vector is defective in E1B55K function. The vectors of the present invention are capable of replication and lysis of neoplastic cells. The vectors may optionally include modifications to the genome so as to impart additional therapeutic or targeting functions. The present invention also provides pharmaceutical formulations of such vectors. The present invention further provides methods of use of such vectors. The present invention further provides methods of preparing the vectors.