TREATMENT OF BRAIN CHANGES WITH MYELIN PROTECTIVE AGENTS

摘要

A method is proposed to treat with myelin protective agents Alzheimer's disease and other conditions satisfying the retrogenic neuropathologic vulnerability model. These conditions include normal brain aging, mild cognitive impairment and specific non-AD dementing disorders. Such agents are vitamin B-12 (cobalamin), homocysteine modulators (containing vitamin B-12, folate [folic acid], vitamin B-6 [pyridoxine] and/or betain [trimethylglycine]), a calpain-inhibitor, or interferon-beta. Another treatment is to maintain lipid reparative mechanisms to lessen the progressive destruction of myelin pathways in the patient's brain. Such reparative mechanisms are cholesterol levels or cholesterol transport.