| 摘要 |
<p>Sulfonamide derivatives exhibiting matrix metalloprotease inhibiting effects, which are compounds represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts of both, or hydrates of them: wherein A is a group represented by the general formula (Ia): (wherein R5 is hydrogen or the like), or the like; R1 is hydroxyl or the like; R2 is a single bond, optionally substituted arylene, or optionally substituted heteroarylene; R3 is a single bond, -C C-, or the like; R4 is optionally substituted aryl, optionally substituted heteroaryl, or the like; and m is 0 or 1.</p> |
