| 摘要 |
Substrates for thioredoxin reductase, containing compounds represented by general formula (1) or (1') (such as 2-phenyl-1,2-benzisoselenazol-3(2H)-one or open-ring derivatives thereof) (wherein R1 and R2 are each hydrogen, halogeno, trifluoromethyl, or the like; R3 is aryl, an aromatic heterocyclic group, or the like; R4 is hydrogen, hydroxyl, an -S-.alpha.-amino acid group , or the like; R5 is hydrogen or C1-C6 alkyl; Y is oxygen or sulfur; and n is an integer of 0 to 5, with the proviso that the selenium atom may be oxidized). These substrates are reduced by thioredoxin reductase in the presence of NAD PH and enhance the peroxidase activity of thioredoxin reductase. |
