Verfahren zur Herstellung eines Rings zur gesteuerten Freigabe eines Therapeutikums

摘要

The specification describes and claims a method of making therapeutic rings from a curable silicone rubber based composition. The rings are capable of controlled release of the therapeutic agent in the human or animal body. The method includes the steps of: (i) extruding a first composition comprising a therapeutic agent and a first elastomer-forming silicone composition to provide a core; (ii) extruding a second composition comprising a second elastomer-forming silicone composition to provide a sheath enclosing the core; (iii) bringing together end portions of a piece of extruded core and sheath to form a ring, (iv) effecting crosslinking of the extruded core, and (v) effecting crosslinking of the extruded sheath.