THE PREPARATION OF trans-4-AMINO-2-CYCLOPENTENE-1-CARBOXYLIC ACID DERIVATIVES

摘要

A process for the preparation of an enantiomerically enriched trans-1,4-disubstituted 2-cyclopentene of formula (4), substantially free of the corresponding cis isomer, comprises selective hydrolysis of a mixture of diastereomeric esters (5) and (8) or their opposite enantiomers, in the presence of an enzyme, wherein R<1> is H or alkyl, R<2> is alkoxy, alkyl, aryl or H, R<3> is H or any non-interfering organic group, and R<4> is alkyl.