摘要 |
Dithiocarbonimidate derivatives of general formula (1), prodrugs thereof, or pharmaceutically acceptable salts of both, useful as organ or tissue fibroplasia inhibitors and other drugs wherein R<1> is alkyl, alkenyl, alkynyl, or cycloalkyl; E is C1-C5 alkylene, C3-C5 alkenylene, or C3-C5 alkynylene; A is nitrogenous heteroaryl or a group represented by general formula (2) (wherein R<2> is hydrogen or a substituent; and R<3> is hydroxyl, alkoxy, alkenyloxy, alkynyloxy, or -NR<4>R<5>); and Ar is aryl or heteroaryl. |