Process of peptidic synthesis starting from N-carboxyanhydride amino acids

摘要

Peptides are prepd. by the following method: (a) an N-(N'-nitroso-N'-(R')carbamoyl) aminoacid of formula (I) is prepd.; (b) is decomposed into N2, R'OH and an N-carboxy anhydride aminoacid of formula (II); (c) (II) is reacted with an amino acid or a peptide having at least one free alpha -amino group to form a dipeptide or a higher peptide cf the one added to the reaction. prepn. of the intermediate (II) by decomposition of (I) is also claimed. R1, R2 = H or alkyl, cycloalkyl, aryl or aralkyl, opt. substd. by 1 or more of OH, SH, NH2, sulphide, acid or amide functions; R' = H, methyl, or 2-chloroethyl,