发明名称 |
Inhibitors of farnesyl-protein transferase |
摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the famesylation of the oncogene protein Ras.
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申请公布号 |
US6127366(A) |
申请公布日期 |
2000.10.03 |
申请号 |
US19980166271 |
申请日期 |
1998.10.05 |
申请人 |
MERCK & CO., INC. |
发明人 |
KIM, BYEONG M.;SHAW, ANTHONY W.;GRAHAM, SAMUEL L.;DESOLMS, S. JANE;CICCARONE, TERRENCE M. |
分类号 |
C07D233/24;C07D401/12;(IPC1-7):A61K31/535;C07D413/06 |
主分类号 |
C07D233/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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