| 摘要 |
PROBLEM TO BE SOLVED: To obtain a medicine having excellent inhibiting actions on emesis caused by a drug having emetic actions by including a compound having excellent antagonistic actions on tachykinin receptors and the drug in combination. SOLUTION: This medicine is obtained by including (A) a compound represented by the formula [ring M is a heterocyclic ring having N=C, CON or the like as a partial structure X=Y; Ra and Rb together are bound to form ring A, H or a substituent group in the ring M; rings A and B are each a (substituted)heterocyclic ring or the like; ring C is a (substituted)heterocyclic ring or the like; ring Z is a (substituted)nitrogen-containing heterocyclic ring; n is 1-6], e.g. (9S)-7-[3,5-bis(trifluoromethyl)benzyl]-6,7,8,9,10,12-hexahydro-9- methyl-6,12-dioxo-5-phenyl[1,4]diazepino[2,1-g][1,7]naphthyridine and (B) a drug having emetic actions (e.g. a carcinostatic agent, an antibiotic, morphine or apomorphine) in combination.
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