| 发明名称 |
2'-O-aminooxy-modified oligonucleotides |
| 摘要 |
Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
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| 申请公布号 |
US6127533(A) |
申请公布日期 |
2000.10.03 |
| 申请号 |
US19980016520 |
申请日期 |
1998.01.30 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP DAN;MANOHARAN, MUTHIAH;KAWASAKI, ANDREW MAMORU |
| 分类号 |
A61K31/7072;A61K31/7076;A61P43/00;C07H15/203;C07H19/04;C07H19/06;C07H19/16;C07H21/00;(IPC1-7):C07H21/02 |
主分类号 |
A61K31/7072 |
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