发明名称 |
Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
摘要 |
This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of detecting the consumption of a fumonisin or a fumonisin analog in a subject comprising (A) detecting, in a sample from the subject, the state of the metabolic pathway of sphingolipids and (B) comparing the state of the metabolic pathway to that of a normal subject, the presence of a change in the state of the metabolic pathway indicating the consumption of a fumonisin or a fumonisin analog. Also provided is a method of detecting the presence of a fumonisin or fumonisin analog contamination in a sample from a food or feed comprising detecting a reaction of the metabolic pathway of sphingolipids, the presence of the reaction indicating the presence of a fumonisin or fumonisin analog contamination. Furthermore, novel fumonisin analogs and compositions comprising fumonisins and fumonisin analogs are provided.
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申请公布号 |
US6127578(A) |
申请公布日期 |
2000.10.03 |
申请号 |
US19960627499 |
申请日期 |
1996.04.04 |
申请人 |
EMORY UNIVERSITY;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE |
发明人 |
MERRILL, JR., ALFRED H.;WANG, ELAINE W.;LIOTTA, DENNIS C.;RILEY, RONALD T. |
分类号 |
A61K31/13;A61K31/22;A61K31/225;C07C215/10;(IPC1-7):C07C215/00 |
主分类号 |
A61K31/13 |
代理机构 |
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地址 |
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