Method for reductively alkylating glycopeptide antibiotics preferably A82846B (chloroorienticin A)

摘要

A method for reductively alkylating a glycopeptide antibiotic (A282846B) comprising an amine-containing saccharide at N<4> and one or more other amines, which comprises reacting a soluble copper complex of the glycopeptide antibiotic with a ketone or aldehyde in the presence of a reducing agent which is sodium cyanoborohydride or pyridine.borane complex. Also disclosed is a copper complex with A82846A or A82846B.