Delivery of nucleic acid into a cell

摘要

An in vitro method for introducing nucleic acid into a cell comprising exposing the cell to a compound with the above formula, wherein: w is a nucleic acid x is a peptide or amino acid y is a linker having a chain length equivalent to 1 to 20 carbon atoms or is absent R4 is H or CH2O-R3, and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, hydroxyl or an acyl group derived from a fatty acid having a carbon chain of 3 to 24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 and R3 is an acyl group derived from a fatty acid. Also disclosed is a compound containing the above formula that is used to introduce nucleic acid into a cell.