发明名称 |
TRANSFORMED ENDOTHELIAL CELLS. |
摘要 |
<p>Endothelial cells which express a protein having I kappa B activity such that NF kappa B activation of the cells is substantially blocked may be prepared by altering the genetic material of the cells so that I kappa B activity is expressed continuously, immediately following endothelial cell activiting stimuli or on demand in response to a predetermined external stimulus e.g. by introducing heterologous I kappa B coding sequences or promoters into the cells. Organs and tissue comprising such endothelial cells are useful in transplantation e.g. xenotransplantation, as they are advantageously less susceptible to rejection.</p> |
申请公布号 |
GR3033600(T3) |
申请公布日期 |
2000.09.29 |
申请号 |
GR20000401135T |
申请日期 |
2000.06.30 |
申请人 |
SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
BACH, FRITZ, H.;DE MARTIN, RAINER |
分类号 |
A61K38/39;A01K67/027;A61K35/12;A61K38/00;A61K48/00;A61P37/06;C07H21/04;C07K14/47;C07K14/78;C12N5/10;C12N15/09;C12N15/12;C12N15/85;(IPC1-7):C12N15/12;C12N15/86 |
主分类号 |
A61K38/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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