| 摘要 |
The compounds of formula I inhibit prolyl-4-hydroxylase and therefore lead to an inhibition of collagen biosynthesis. The compounds may be used in a medicament to treat fibrotic disorders of the lung, kidney, heart, eye and skin, and to treat artherosclerosis. In formula I; R1, R2 and R3 are Hydrogen, R4 is (C1-C6)-alkyl, A is CH2, in which a Hydrogen can be replaced by a methyl group, and B is CO2G, wherein G is a branched or unbranched or cyclic (C1-C20)-alkyl, a branched or unbranched or cyclic (C2-C20)-alkenyl or alkinyl radical, a corresponding (C4-C20)-alkeninyl radical, a retinyl radical, or an optionally substituted phenylalkyl radical.
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