| 摘要 |
A use in the manufacture of a medicament for the treatment of sexual dysfunction of a compound of the following general formula (I) wherein, R1 is selected from N and CH, m is 0 or 1, R2 is selected from (CR8)2)n-m and (Cn-mR8)2(n-m)2' in which n is 4, 5, 6, or 7, the R8's in any single compound being the same or different, each R8 being selected from H and C1-C6 alkyl, or one R8 being combined with either R3 or R7 to form a single bond linking the no. 3' ring vertex to either the no. 2 or the no. 6 ring vertices or a single divalent linking moiety linking the no. 3' ring vertex to either the no. 2 or the no. 6 ring vertices, the linking moiety being a member selected from the group consisting of CH2, CH2-CH2, CH=CH, O, NH, N(C1-C6 alkyl), N=CH, N=C(C1-C6 alkyl), C(O), O-C(O), C(O)-O, CH(OH), NH-C(O), and N(C1-C6 alkyl)-C(O), R3, when not combined with R8, is selected from H, C1-C6 alkyl, and C1-C6 alkoxy, R4 is either combined with R5 or is selected from H, OH, and C1-C6 alkoxy, R5 is either combined with R4 or is selected from H, OH, C1-C6 alkoxy, amino, mono(C1-C6 alkyl)amino, di(C1-C6 alkyl)amino, and CH2OR9, in which R9 is selected from H, C1-C6 alkyl, an aromatic carbocyclic moiety, an aromatic heterocyclic moiety, an aromatic carbocyclic alkyl moiety, an aromatic heterocyclic alkyl moiety, and any such moiety substituted with one or more members selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, hydroxy, halo, amino, alkylamino, dialkylamino, and methylenedioxy, R6 is H or CH2OR9, R4 and R5 when combined form a member selected from the group consisting of (II), (III), (IV) and (V) in which, R10 is selected from O, NH and N(C1-C6 alkyl), R11 is selected from O, NH and N(C1-C6 alkyl), R12 is selected from H and C1-C6 alkyl, and when two or more R12's are present in a single compound, such R12's are the same or different, p is 1, 2, or 3, q is 1 or 2 and R7, when not combined with any R8, is selected from H, C1-C6 alkyl and C1-C6 alkoxy. These compounds enhance the stimulation of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptors.
|
