Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin

摘要

The specification describes a method for purifying recombinant neurotrophins, particularly those in the NGF-family, more particularly nerve growth factor (NGF) and neurotrophin-4/5 (NT-4/5), and neurotrophin-3 (NT-3) from variants, impurities, and contaminants associated therewith, particularly when produced by bacterial or mammalian cell fermentation.