发明名称 |
IMMUNOMODULATORY STEROIDS, IN PARTICULAR THE HEMIHYDRATE OF 16.ALPHA.-BROMOEPIANDROSTERONE |
摘要 |
The invention provides compositions comprising formula 1 steroids, e.g., 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make improved pharmaceutical formulations. The invention also provides methods of intermittent dosing of steroid compounds such as analogs of 16alpha-bromo-3beta-hydroxy-5alpha- androstan-17-one and compositions useful in such dosing regimens. The invention further provides compositions and methods to inhibit pathogen (viral) replication, ameliorate symptoms associated with immune dysregulatio n and to modulate immune responses in a subject using certain steroids and steroid analogs. The invention also provides methods to make and use these immunomodulatory compositions and formulations.
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申请公布号 |
CA2365081(A1) |
申请公布日期 |
2000.09.28 |
申请号 |
CA20002365081 |
申请日期 |
2000.03.23 |
申请人 |
HOLLIS-EDEN PHARMACEUTICALS, INC. |
发明人 |
HEGGIE, WILLIAM;FRINCKE, JAMES MARTIN;AHLEM, CLARENCE NATHANIEL;DE CARVALHO, LUIS DANIEL DOS ANJOS;PRENDERGAST, PATRICK T.;READING, CHRISTOPHER L.;VERNON, RUSSELL NEIL;THADIKONDA, KRUPAKAR PAUL |
分类号 |
A61K31/565;A61K31/5685;A61K31/58;A61P31/04;A61P31/12;A61P31/18;A61P31/20;A61P33/00;A61P35/00;A61P37/00;C07J1/00;C07J3/00;C07J9/00;C07J17/00;C07J53/00;C07J73/00;(IPC1-7):C07J1/00 |
主分类号 |
A61K31/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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