THIOUREA AND UREA LIQUID-PHASE COMBINATORIAL LIBRARIES: SYNTHESIS AND APOPTOSIS INDUCTION
摘要
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds of formula (I), in which X is S or O; R and R>1< are individually (CHR) -Ar; and the other variables are as defined in the claims. In addition, the invention relates to methods for construction combinatorial chemistry libraries containing thiourea and urea compounds. Furthermore, this invention relates to methods for the identification of bioactive thiourea and urea compounds as well as compositions and therapeutic methods for treating cancer.
申请公布号
WO0056681(A1)
申请公布日期
2000.09.28
申请号
WO2000US06989
申请日期
2000.03.18
申请人
PARKER HUGHES INSTITUTE;ZHU, ZHAOHAI;MAO, CHEN;NARLA, RAMA, K.;UCKUN, FATIH, M.
发明人
ZHU, ZHAOHAI;MAO, CHEN;NARLA, RAMA, K.;UCKUN, FATIH, M.