MATERIALS AND METHODS RELATING TO MODULATION OF p66 EXPRESSION
摘要
It has been determined that i) p66<shc> is serine phosphorylated upon UV treatment or oxidative damage; ii) the serine-phosphorylation of p66 by oxidative signals is mediated by Erk1 and p38, as shown both in vivo and in vitro; iii) ablation of p66<shc> expression by homologous recombination enhances resistance to oxidative damage both in vitro and in vivo; iv) a serine-phosphorylation defective mutant of p66<shc> is unable to restore a normal stress response in p66<shc> targeted cells; v) mice carrying the p66<shc> targeted mutation have prolonged lifespan.
申请公布号
WO0056886(A1)
申请公布日期
2000.09.28
申请号
WO2000GB01079
申请日期
2000.03.22
申请人
CANCER RESEARCH VENTURES LIMITED;PELICCI, PIER, GIUSEPPE;GIORGIO, MARCO;MIGLIACCIO, ENRICA;LANFRANCONE, LUISA