PEPTIDES BLOCKING RESPONSE TO CHEMICAL SUBSTANCES OR THERMAL STIMULI OR NOCICEPTOR INFLAMMATION MEDIATORS AND COMPOSITIONS CONTAINING SAID PEPTIDES

摘要

The invention relates to peptides (I): aa1-X-aa2, wherein aa1 represents the amino acid radical of the amino end, aa2 represents the amino acid radical of the carboxylic end and X represents a radical of 2 to 8 amino acids, which are identical or different, contained between aa1 and aa2, and to their pharmaceutically acceptable salts with the proviso that at least 3 of the aminoacids are basic aminoacids and that at least one of the aminoacids is an aromatic aminoacid. Said peptides (I) can block the ionic channels that are activated by exogenous chemical substances, thermal stimuli or inflammation mediators, e.g. nocireceptor VR1 and rL-glutamate ionotropic receptors and are suitable for treating disorders mediated by the activity of said receptors, e.g. peripheral pain sensation.