composition in the form of a microsphere comprising a therapeutic agent incorporated in a polysaccharide for the pulmonary delivery of drugs

摘要

The composition for delivery of pharmacological agents to the respiratory tract of a mammal to provide peripheral deposition and systematic uptake wherein the therapeutic agent is incorporated into a polysaccharide through the process of spray drying a mixture of the agent and a polysaccharide provided that the composition cannot be in the form of a glass. The polysaccharide is either in an aqueous solution or in the aqueous phase of an emulsion. The composition provides an immediate release of the pharmacological agent once deposited in the lungs. The pharmacological agent can be insulin, heparin, DNA, an oligosaccharide or calcitonin. The polysaccharide can be soluble starch, polyglucosamine, amylopectin, amylose, dextran, pullulan or amylodextrin.