Mutants of Rb and p53 genes and use for the regulation of cell growth and treatment of cancerous and non-cancerous proliferative diseases

摘要

An isolated synthetic mutated Rb gene encoding a mutated functionally active retinoblastoma protein. The Rb gene is mutated by changing nucleotides that encode for amino acids in conserved homology regions P1, P3 and P5. Also disclosed is the use of the Rb gene for the treatment of pathological cell proliferative diseases, wherein the treatment comprises administration to a non-cancerous or cancerous proliferating cell of the DNA molecule.