| 摘要 |
The present invention relates to compounds of formula (I) wherein: R1, R2, R 3, R4, R5, R9 and R10 represent a variety of substituents; R6 represents hydrog en or a C1-4alkyl group optionally substituted by a hydroxy group; R7 represent s halogen, hydroxy, optionally substituted C2-4alkenyl, optionally substituted C2-4alkynyl, N3, -NR11R12, -NRaCORb, -OSO2Ra, -(CH2)pNRa(CH2)qCOORb, CORa, COORa, -N=C=O, or a five membered or six membered nitrogen-containing heteroaromatic ring optionally containing 1, 2 or 3 additional heteroatoms selected from N, O and S which heteroaromatic ring is optionally substituted at any substitutable position by a substituent selected from =O, =S, halogen , hydroxy, -SH, CORa, CO2Ra, -ZNR11R12, C1-4alkyl, hydroxyC1-4alkyl, fluoroC1- 4alkyl, chloroC1-4alkyl, C1-4alkoxy, fluoroC1-4alkoxy or C1-4alkoxy substituted by a C1-4alkoxy or hydroxyl group; R8 represents hydrogen, C1- 6alkyl, fluoroC1-6alkyl, hydroxy, C1-6alkoxy or hydroxyC1-6alkyl; and n is zero, 1 or 2; or a pharmaceutically acceptable salt thereof. The compounds a re of particular use in the treatment or prevention of depression, anxiety, pai n, inflammation, migraine, emesis or postherpetic neuralgia.
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