| 发明名称 |
TREATMENT OF LFA-1 ASSOCIATED DISORDERS WITH INCREASING DOSES OF LFA-1 ANTAGONIST |
| 摘要 |
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need therof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
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| 申请公布号 |
CA2367025(A1) |
申请公布日期 |
2000.09.28 |
| 申请号 |
CA20002367025 |
申请日期 |
2000.03.17 |
| 申请人 |
XOMA TECHNOLOGY LTD.;GENENTECH, INC. |
发明人 |
STARKO, KAREN;DEDRICK, RUSSELL L.;GAROVOY, MARVIN R.;KRAMER, SUSAN M. |
| 分类号 |
A61K45/00;A61K38/00;A61K39/395;A61P11/00;A61P11/06;A61P17/06;A61P25/28;A61P29/00;A61P37/06;A61P37/08;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A61K45/00 |
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