发明名称 |
RNA Polymerase I Transkriptionsfaktor TIF-IA |
摘要 |
The invention relates to an RNA polymerase I transcription factor TIF-IA and related proteins the concentration and/or activity of which is correlated with the cell proliferation rate, and to DNA sequences encoding said proteins. The invention also relates to ligands and antagonists binding to RNA polymerase I transcription factor TIF-IA or related proteins, and to antisense RNAs or ribozymes directed against the expression of TIF-IA. The inventive compounds are useful in the prophylaxis or treatment of diseases that are related to an increased or a reduced cell proliferation.
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申请公布号 |
DE19911992(A1) |
申请公布日期 |
2000.09.28 |
申请号 |
DE19991011992 |
申请日期 |
1999.03.17 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS |
发明人 |
GRUMMT, INGRID;VINGRON, MARTIN |
分类号 |
A61K38/00;C07K14/47;C12N15/113;C12N15/12;(IPC1-7):C07K14/435;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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