| 摘要 |
Water soluable taurine derivatives, and methods of synthesizing, formulating, and using such taurine derivatives for treating or protecting the retina of a mammalian eye. The invention includes treatment methods which comprise contacting with the retinal tissue, a therapeutically effective amount of retinyliden tauret (3,7-dimethyl-9-(2,6,6-trimehyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-imido-(N-ethane sulfonic acid)). The invention also includes methods for synthesizing two (2) specific isomers of retinyliden tauret, namely (A) all-trans-[3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-imido-(N-ethane sulfonic acid)] and (B) 11-cis-[3,7-dimethyl-9-(2,6,6-trimehyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-imido-(N-ethane sulfonic acid)]. Also included are formulations and methods for administering such compounds to the retina of a mammalian eye to treat or prevent the progression of retinopathy. |
