Agent for increasing chemokine production

摘要

The present invention concerns the use of an extract from inflammatory tissue inoculated with vaccinia virus as active component in an agent for increasing chemokine production which is useful for the treatment of AIDS. The extracts from inflammatory tissue inoculated with vaccinia virus have increasing effects in the production of chemokines such as MIP-1 alpha , MIP-1 beta and RANTES which are HIV-suppressive factors released from CD8<+>T cells. The extracts also have suppressive effects on SIV infection and on SIV replication. Therefore, such an extract is useful in an anti-HIV drug with new mechanisms of action which are different from those of known therapeutic agents for AIDS such as reverse transcriptase inhibitors and protease inhibitors, and an agent comprising this extract is very useful as a new drug for the treatment of AIDS with high safety.