| 发明名称 |
High affinity TGF beta nucleic acid ligands and inhibitors |
| 摘要 |
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF beta . Included in the invention are specific RNA ligands to TGF beta 1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF beta 1 with its receptor.
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| 申请公布号 |
US6124449(A) |
申请公布日期 |
2000.09.26 |
| 申请号 |
US19980046247 |
申请日期 |
1998.03.23 |
| 申请人 |
NEXSTAR PHARMACEUTICALS, INC. |
发明人 |
GOLD, LARRY;PAGRATIS, NIKOS |
| 分类号 |
A61K38/00;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07K14/00;C07K14/49;C07K14/495;C07K14/50;C12N9/12;C12N15/10;C12N15/113;C12N15/115;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76;(IPC1-7):C07H21/04 |
主分类号 |
A61K38/00 |
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