Process for preparing (s)- and (R)- alpha -ethyl-2-oxo-1-pyrrolidineacetamide

摘要

The present invention relates to a process for preparing (S)- and (R)- alpha -ethyl-2-oxo-1-pyrrolidineacetamide and (R)- alpha -ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of alpha -ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase. This process makes it possible to achieve good production efficiency on the industrial scale.