| 摘要 |
PROBLEM TO BE SOLVED: To obtain a safe hypocholesterolemic agent which can easily be taken and exhibits a significant ultra low density lipoprotein cholesterol-lowering action and a significant neutral fat-lowering action by adding a hydrolyzate obtained by hydrolyzing dried fish with thermolysin. SOLUTION: This hypocholesterolemic agent contains a hydrolyzate obtained by hydrolyzing dried fish with thermolysin, preferably a hydrolyzate, such as an oligosaccharide, for example, Ile-Trp-His-Thr or Ala-Leu-Pro-His-Ala, obtained by adding (B) water and (C) thermolysin to (A) dried fish, preferably sliced or granular dried bonito, and then hydrolyzing the component A preferably at 10-80 deg.C at pH 4-8. Therein, the component C is preferably added to 0.05-5.0 wt.% based on the total amount of the components A and B. The hypocholesterolemic agent is preferably taken at a dose of 0.1-10 g once to three times a day. |
