发明名称 |
Method for preparation of pharmaceutical-grade dithiocarbamate |
摘要 |
The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a pharmaceutically acceptable diluent that is a solvent for the carbon disulfide, but not for the secondary amine in an inert gas atmosphere, cooling the mixture so as to precipitate the dithiocarbamate therefrom, and separating the precipitated dithiocarbamate from the cooled mixture. The preferred solvent contains absolute ethanol. In alternative embodiments, the invention further provides methods for purifying a dithiocarbamate to obtain a pharmaceutical-grade dithiocarbamate particulate from a dithiocarbamate feed and methods for producing a sterile pharmaceutical-grade dithiocarbamate from a dithiocarbamate feed.
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申请公布号 |
US6124349(A) |
申请公布日期 |
2000.09.26 |
申请号 |
US19990252901 |
申请日期 |
1999.02.18 |
申请人 |
MEDINOX, INC. |
发明人 |
VASSILEV, VASSIL P.;LIAW, WEI-CHENG;LAI, CHING-SAN |
分类号 |
A61K31/325;C07C333/16;(IPC1-7):A01N47/10 |
主分类号 |
A61K31/325 |
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