发明名称 |
Compositions and methods for reducing adhesiveness of defective red blood cells |
摘要 |
Peptide sequences and analogs thereof based on amino acid motifs in band 3 which are effective in reducing the adhesiveness of pathologically adhesive red blood cells. One class of peptide sequences are characterized by the sequence motif Z1xKxxx+ (SEQ ID NO:45), wherein Z1 is selected from the group consisting of tyrosine, phenylalanine and alanine; x is an unobstructive residue and + is a positively charged residue (e.g., K or P-H). These peptides are used to reduce adhesiveness in the treatment of sickle cell disease, thalassemia and diabetes. A second class of peptide sequences are characterized by the sequence motif Z2Z3Z2-x-xxxx- (SEQ ID NO:46), wherein Z2 represents a hydrophobic residue, x is an unobstructive residue and - is a negatively charged residue. These peptides can be used to reduce adhesiveness in the treatment of malria, sickle cell disease, thalassemia and diabetes.
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申请公布号 |
US6124262(A) |
申请公布日期 |
2000.09.26 |
申请号 |
US19950405647 |
申请日期 |
1995.03.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SHERMAN, IRWIN WILLIAM;CRANDALL, IAN EDWARD;SHOHET, STEPHEN BYRON;THEVENIN, BERNARD JEAN-MARIE |
分类号 |
A61K38/00;C07K14/705;C07K16/20;(IPC1-7):A61K38/00;C07K5/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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